Enthalpy and entropy changes on molecular inclusion of 1-heptanol into α- and β-cyclodextrin cavities in aqueous solutions

The enthalpies of transfer of 1-heptanol from aqueous to aqueous α- or β-cyclodextrin (CD) solutions have been determined by microcalorimetry at various mole fractions at 298.15 K. 1-Heptanol greatly stabilized in enthalpy in an α-CD cavity, accompanying a large entropy decrease. On the other hand, the enthalpy changes on inclusion into a β-CD cavity is too large and exothermic. This is the first case in a series of the system of β-CD+n-alkane-1-ols.