Title of article
Thermodynamics of complexes between nucleobase-modified β-cyclodextrins and bile salts
Author/Authors
Yu Liu، نويسنده , , Qian Zhang، نويسنده , , Dongsheng Guo، نويسنده , , Rui-Jie Zhuang، نويسنده , , Lihua Wang، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2008
Pages
5
From page
108
To page
112
Abstract
The binding of three nucleobase-modified β-CDs, (i.e., mono(6-ade-6-deoxy)-β-CD 2, mono(6-thy-6-deoxy)-β-CD 3, and mono(6-ura-6-deoxy)-β-CD 4) with four bile salts (deoxycholate, DCA; cholate, CA; glycocholate, GCA; and taurocholate, TCA) were investigated by means of circular dichroism, 2D NMR spectroscopy and calorimetric titration. The results show the binding of host 2 with bile salts is weaker and different from hosts 3 and 4. Enthalpy changes between hosts 2–4 and bile salts are much more favorable than those of native β-CD 1, whereas the entropy changes are unfavorable.
Keywords
Microcalorimetric titration , molecular recognition , Cyclodextrin , Bile salt
Journal title
Thermochimica Acta
Serial Year
2008
Journal title
Thermochimica Acta
Record number
1201548
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