Author/Authors :
Zolfaghari، B. نويسنده Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. , , Shokoohinia، Y. نويسنده Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, I.R. Iran. , , Ramezanlou، P. نويسنده Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. , , Sadeghi، A. نويسنده Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. , , Mahmoudzadeh، M. نويسنده Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. , , Minaiyan، M. نويسنده ,
Abstract :
Allium elburzense (A. elborzense, Alliaceae), a plant rich in saponins, is an edible vegetable in northern Iran with a folk background use as antidiabetic which has not yet been examined for this indication. To evaluate the antidiabetic potential of A. elburzense, its hydroalcoholic (HdAE) and butanolic extracts (BuE) were examined. The acute (1, 2, 3, 4, 8 h) and sub-acute (11 days) effects of oral (p.o.) and intraperitoneal (i.p.) administration of HdAE and BuE of A. elburzense bulbs in different doses were evaluated on blood glucose levels of normal and streptozotocin (STZ, 55 mg/kg body weight)-induced diabetic rats. Glibenclamide (1 mg/kg b.w.) was used as reference drug. Sub-acute treatment with HdAE for 11 days reduced significantly blood glucose levels in diabetic rats (at least P < 0.05), while BuE was effective only following i.p. administration (P < 0.01). Acute administration did not reduce blood glucose level in normal and diabetic animals. It is concluded that HdAE of A. elburzense exhibited a significant antihyperglycemic activity following chronic administration. These results provide evidence for potential use of A. elburzense in diabetes mellitus considering the fact that this plant is endemic to a location of Iran where diabetes is a high prevalence disorder.
