Author/Authors :
Mpiana، P.T. نويسنده , , Mudogo، v. نويسنده , , Kabangu، Y.F. نويسنده , , Tshibangu، D.S.T. نويسنده , , Ngbolua، K.N. نويسنده , , Atibu، E.K. نويسنده , , Mangwala، K.p. نويسنده , , Mbala، M.B. نويسنده , , Makelele، L.K. نويسنده , , Bokota، M.T. نويسنده ,
Abstract :
Antisickling activity of anthocyanins extract from a Congolese plant (Hymenocardia acida Tul.) was
evaluated using Emmel test. Chromatographic separations using chloroform-benzene (2:1) provided three
fractions A1 A2 and A3 with the most polar [A1 (TLC, Rf= 0.21)] exhibiting the highest activity. Thermal kinetic
degradation of this fraction at 100 and 120°C produced a first order rate constants k = 2.64*l 0^(-4) and 4.08*l0^(-4), respectively. Structural elucidation of isolated compounds is in progress.
Keywords :
Sickle cell anaemia , drepanocytes , thermodegradation , degradation kinetics
