Author/Authors :
Madhuvanthi A. Kandadai، نويسنده , , Rajasekhar Anumolu، نويسنده , , Xiaojun Wang، نويسنده , , Durairaj Baskaran، نويسنده , , Leonard F. Pease III، نويسنده , , Dmitry Bedrov، نويسنده , , Grant D. Smith، نويسنده , , Jimmy W. Mays، نويسنده , , Jules J. Magda، نويسنده ,
Abstract :
Rheological evidence is provided demonstrating that covalent grafting of monodisperse isotactic poly(l-leucine) branches onto linear hyaluronan (HA) polysaccharide chains yields comb-branched HA chains that self-assemble into long-lived physical networks in aqueous solutions driven by hydrophobic interactions between poly(l-leucine) chains. This is in stark contrast to native (unmodified) HA solutions which exhibit no tendency to form long-lived physical networks.
Keywords :
Viscoelasticity , Hyaluronic acid , Polypeptide , Hydrophobic interaction
