Title of article :
Earrings and padlocks for the double helix: topological labeling of duplex DNA
Author/Authors :
Vadim V. Demidov، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 2003
Pages :
4
From page :
148
To page :
151
Abstract :
Concatenation of hybridization probe with DNA target is crucial for highly localized detection of targeted sequences and might also be used in various gene-therapy applications. Several approaches based on the attachment of a circular oligonucleotide to designated DNA sites have been proposed. Recently, earring-like probes provide a true topological linkage between a probe and the target, thus allowing the DNA labeling by essentially immobile tags. The latest development in this direction takes advantage of oligonucleotide uptake by supercoiled DNA and is an important step forward.
Journal title :
Trends in Biotechnology
Serial Year :
2003
Journal title :
Trends in Biotechnology
Record number :
1232904
Link To Document :
بازگشت