Author/Authors :
Ebrahimzadeh-Vesal، Reza Ebrahimzadeh-VesalReza نويسنده Department of Medical Genetics, Medical Sciences/University of Tehran, Iran, PO Box 14155-1595 , , Azam، Roza نويسنده Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Azam, Roza , Ghazarian، Arvin نويسنده Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Ghazarian, Arvin , Hajesmaeili، Mogge نويسنده Department of Biology, Islamic Azad University of Parand, Tehran, Iran Hajesmaeili, Mogge , Ranji، Najmeh نويسنده Department of Genetics, Faculty of Sciences, Islamic Azad University, Rasht Branch, Rasht, Iran Ranji, Najmeh , Ezzati، Mohammad Reza نويسنده Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Ezzati, Mohammad Reza , Sadri، Mehrdad نويسنده Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Sadri, Mehrdad , Mohammadi Nejad، Mohammad Ali نويسنده , , Khavandi، Siamak نويسنده Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Khavandi, Siamak
Abstract :
Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies
before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It
has been suggested that women with thrombophilia have an increased risk of pregnancy loss and
other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot
formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited
predisposition to thrombophilia is most often associated with factor V Leiden mutation,
prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T and A1298C
gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive
blood coagulation.
