Title of article
Human Polynucleotide Phosphorylase, hPNPase, is Localized in Mitochondria
Author/Authors
Jan Piwowarski، نويسنده , , Pawel Grzechnik، نويسنده , , Andrzej Dziembowski، نويسنده , , Aleksandra Dmochowska، نويسنده , , Michal Minczuk، نويسنده , , Piotr P. Stepien، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
853
To page
857
Abstract
The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.
Keywords
Mitochondria , RNA degradation , PNPase , polynucleotide phosphorylase
Journal title
Journal of Molecular Biology
Serial Year
2003
Journal title
Journal of Molecular Biology
Record number
1242736
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