DM2 CCTG•CAGG Repeats are Crossover Hotspots that are More Prone to Expansions than the DM1 CTG•CAG Repeats in Escherichia coli

Myotonic dystrophy type 2 (DM2) is caused by the extreme expansion of the repeating tetranucleotide CCTG•CAGG sequence from <30 repeats in normal individuals to ?11، نويسنده , , 000 for the full mutation in certain patients. This repeat is in intron 1 of the zinc fing، نويسنده ,

روزنامه با شماره پیاپی سال 2006

16

21

36

SOS repair , expansions , DNA thermodynamic stabilities , Recombination , tetranucleotide repeats

Journal of Molecular Biology

2006

Journal of Molecular Biology

1248140