Author/Authors :
Andreas F.-P. Sonnen، نويسنده , , Chao Yu، نويسنده , , Edward J. Evans، نويسنده , , David I. Stuart، نويسنده , , Raymond J. Owens and Simon J. Davis، نويسنده , , Robert J.C. Gilbert، نويسنده ,
Abstract :
We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis–trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits.
