Title of article
Induction of MuRF1 Is Essential for TNF-α-Induced Loss of Muscle Function in Mice
Author/Authors
Volker Adams PhD، نويسنده , , Norman Mangner، نويسنده , , Alexander Gasch، نويسنده , , Christian Krohne، نويسنده , , Stephan Gielen، نويسنده , , Stephanie Hirner، نويسنده , , Hermann-Josef Thierse، نويسنده , , Christian C. Witt، نويسنده , , Axel Linke، نويسنده , , Gerhard Schuler، نويسنده , , Siegfried Labeit، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
12
From page
48
To page
59
Abstract
Humoral circulating inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) can impair skeletal muscle contractility. Furthermore, TNF-α expression correlates with elevated levels of atrogin-like muscle-specific ubiquitin E3 ligases, which are presumed to mediate muscle protein breakdown and atrophy. However, the casual relationships between MuRF1 and TNF-α and their relative contributions to muscle function impairment are not known.
Keywords
skeletal muscle function , Myopathy , MuRF1 , cytokines , ubiquitin E3 ligases
Journal title
Journal of Molecular Biology
Serial Year
2008
Journal title
Journal of Molecular Biology
Record number
1257715
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