A new dual fluorescent probe preparation and its biodiagnose function in vitro

A new dual fluorescent probe was prepared by encapsulating the complex of cerium (III) and quinizarin into silica nanoparticles. Cerium (III) and quinizarin can form a stable dual fluorescent complex in ethanol, but this complex would dissociate in the aqueous medium, which limited its application in biosystem. So, such complex was encapsulated inside the silica nanoparticles to solve this problem. The results indicated that the stability and water solubility of the complex were greatly improved after been encapsulated into the silica nanoparticles. In addition, its dual fluorescent probe function was studied in vitro.