Author/Authors :
Hassanzadeh، F. نويسنده Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. , , Rahmani Khajouei، M. نويسنده Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R.Iran. , , Hakimelahi، GH نويسنده , , Jafari، E. نويسنده , , Khodarahmi، GA نويسنده ,
Abstract :
Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures of compounds were confirmed by IR, 1HNMR and Mass spectra.
