Synthesis and anti-HIV activity of new urea and nitrosourea derivatives of diamino acids Original Research Article

A series of N1-methyl, N1-allyl, N1-(2-chloroethyl) and N1-propargyl urea and nitrosourea derivatives of diamino acids (l-omithine and l-lysine) was synthesized and was shown to have weak activity in counteracting the cytopathic effects of the HIV-1 on a T4 lymphocyte cell line (CEM-IW). However, selected compounds may possess some immunomodulatory activity.