Title of article
A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity Original Research Article
Author/Authors
Vladimir Kral، نويسنده , , Eric A. Brucker، نويسنده , , Gregory Hemmi، نويسنده , , Jonathan L. Sessler، نويسنده , , Jarmila Kralova، نويسنده , , Henry Bose Jr، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
573
To page
578
Abstract
The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at μM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1995
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300451
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