Title of article
Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains Original Research Article
Author/Authors
Rogier C. Buijsman، نويسنده , , Jan E.M. Basten، نويسنده , , Cornelia M. Dreef-Tromp، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Constant A.A van Boeckel، نويسنده , , Jacques H. van Boom، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
10
From page
1881
To page
1890
Abstract
The synthesis of three heparin analogues (i.e. compounds ) having perphosphorylated thrombin binding domains (TBDs) is reported. These compounds were tested in vitro for their antithrombin III (ATIII)-mediated anti-Xa and antithrombin activities. Conjugates show a remarkable increase in antithrombin activity compared to the structurally related conjugates with persulfated TBDs (i.e. compounds ), whereas compound displays a diminished activity.
Keywords
Antithrombotics , Enzyme inhibitor , Heparin , Oligosaccharides , Thrombin
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300471
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