Title of article :
Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids Original Research Article
Author/Authors :
Hsing-Pang Hsieh، نويسنده , , James G. Muller، نويسنده , , Cynthia J. Burrows، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Abstract :
Seven new amino- and guanidino-substituted steroids have been synthesized from bile acid precursors, either deoxycholic acid or lithocholic acid. Their DNA binding properties have been examined using an ethidium displacement assay, through studies of hyperchromicity and thermal denaturation, and by circular dichroism. Comparison is made to simple aliphatic polyamines such as putrescine, 1,12-diaminododecane, spermidine, and spermine.
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry