Author/Authors :
Maurizio Botta، نويسنده , , Francesca Occhionero، نويسنده , , Rosario Nicoletti، نويسنده , , Paola Mastromarino، نويسنده , , Cinzia Conti، نويسنده , , Maurizio Magrini، نويسنده , , Raffaele Saladino، نويسنده ,
Abstract :
The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2′-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus.
