Structural functions of antimicrobial long-chain alcohols and phenols Original Research Article

Antimicrobial activity of a series of long-chain alcohols and common naturally occurring alcohols were tested against 15 selected microorganisms in order to gain new insights into their structural functions. The maximum activity seems to depend on the hydrophobic chain length from the hydrophilic hydroxyl group, and also the microorganisms being tested. The results obtained with the alcohols exhibit a generally applicable rule to many other compounds. The structure-antimicrobial activity relationships of a series of long-chain alcohols (C6 to C20) and common naturally occurring alcohols were studied for 15 selected microorganisms. The antimicrobial activity of long-chain alcohols was related to the hydrophobic chain length from the hydrophilic hydroxyl group, and the chain lengths with maximum activity varied depending on the microorganisms tested. The relationships obtained with the alcohols also applied to many other compounds.