Synthesis and antitumor activity of goniofufurone analogues Original Research Article

Synthesis and antitumor activity of goniofufurone analogues , , , , and is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans , to the corresponding lactols , . Cytotoxicities of , , , , and tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone () did not enhance the cytotoxicities significantly.