Synthesis and antiviral effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted guanosine derivatives Original Research Article

2-(2″- and 3″-Thienyl)adenosine and the corresponding furyl derivatives were prepared through Pd(0)-catalyzed coupling of 2′,3′,5′-tri-O-(t-butyldimethylsilyl)-2-iodoadenosine with the appropriate tributyltin derivatives followed by deprotection. Preparation of the 8-(2″- and 3″-thienyl)guanosines and 8-(2″- and 3″-furyl)guanosines followed a similar route. Antiviral properties of these compounds and the related 2,6-diaminopurine ribofuranosides were of no pharmacological interest.