Title of article
Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors Original Research Article
Author/Authors
Lee J. Beeley، نويسنده , , John M. Berge، نويسنده , , Helen Chapman، نويسنده , , Paul Hieble، نويسنده , , John Kelly، نويسنده , , Diane P. Naselsky، نويسنده , , Caroline M. Rockell، نويسنده , , Paul W. Young، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1693
To page
1698
Abstract
The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1995
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300598
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