Author/Authors :
Paul A. Wyman، نويسنده , , Laramie M. Gaster، نويسنده , , Frank D. King، نويسنده , , Jonathon M. Sutton، نويسنده , , Elizabeth S. Ellis، نويسنده , , Kay A. Wardle، نويسنده , , Timothy J. Young، نويسنده ,
Abstract :
The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.
