D-ring substituted rhazinilam analogues: semisynthesis and evaluation of antitubulin activity Original Research Article

Novel (−)- and (+)-rhazinilam derivatives substituted on the D-ring (compounds 3, 4, 5 and 6) have been prepared from (+)-vincadifformine and (−)-tabersonine and evaluated against the disassembly of microtubules into tubulin. Along with this study, a reproducible ‘one pot’ semisynthesis of (−)-rhazinilam from (+)-1,2-didehydroaspidospermidine was performed allowing the easy preparation of these new compounds.