Title of article
Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-Acetylglucosamine sugar with simple C2-symmetric 1,2-diols Original Research Article
Author/Authors
Jeremy C. Prodger، نويسنده , , Mark J. Bamford، نويسنده , , Michael I. Bird، نويسنده , , Paul M. Gore، نويسنده , , Duncan S. Holmes، نويسنده , , Richard Priest، نويسنده , , Victoria Saez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
9
From page
793
To page
801
Abstract
Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex in vitro (IC50 0.5 mM).
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1996
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300770
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