Title of article
Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series Original Research Article
Author/Authors
Béatrice Bonnet، نويسنده , , David Soullez، نويسنده , , Sophie Girault، نويسنده , , Louis Maes، نويسنده , , Valérie Landry، نويسنده , , Elisabeth Davioud-Charvet، نويسنده , , Christian Sergheraert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
9
From page
95
To page
103
Abstract
A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitro trypanocidal potency. The most trypanocidal amongst them was found to be totally inactive towards the enzyme and thus constitutes a lead structure for the identification of new potential Trypanosoma cruzi target(s).
Keywords
Chemotherapy , antiparasitics , polycyclic heterocyclic compounds , Enzyme inhibitors
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300788
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