An efficient synthesis of methyl tetra-o-hexyl gentiooctaoside, an octaosyl analogue of ANP receptor antagonist HS-142-1 Original Research Article

Methyl O-(3-O-hexyl-β-d-glucopyranosyl)-(1 → 6)-[O-(β-d-glucopyranosyl)-(1 → 6)- O-(3-O-hexyl-β-d-glucopyranosyl)-(1 → 6)]3-β-d-glucopyranoside, a 3-O hexyl analogue of the octaosyl component of fungal lipooligosaccharide HS-142-1, was stereo- and regioselectively synthesized as a potent antagonist for the tetrameric atrial natriuretic peptide (ANP) receptors.