Title of article
Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro Original Research Article
Author/Authors
Hanumantharao G. Raj، نويسنده , , Sangita Gupta، نويسنده , , Gopa Biswas، نويسنده , , Suddham Singh، نويسنده , , Amarjit Singh، نويسنده , , Amitabh Jha، نويسنده , , Kirpal S. Bisht، نويسنده , , Sanjay K. Sharma، نويسنده , , Subhash C. Jain، نويسنده , , Virinder S. Parmar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2225
To page
2228
Abstract
Eighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B1-DNA binding in vitro. The contribution of functionality on coumarin nucleus towards the inhibition of AFB1-DNA binding is in the order acetoxy > hydroxy > methoxy. The results illustrate the structure-activity relationship.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1996
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301011
Link To Document