Author/Authors :
Dirk Roeda، نويسنده , , Bertrand Tavitian، نويسنده , , Christine Coulon، نويسنده , , Frédérique David، نويسنده , , Frédéric Dollé، نويسنده , , Chantal Fuseau، نويسنده , , Antoinette Jobert، نويسنده , , Christian Crouzel، نويسنده ,
Abstract :
RPR-72840A, an inhibitor of serotonin reuptake, was labelled with carbon-11. The synthesis of the nonradioactive precursor, which exhibited some unexpected chemistry, and its reaction with [11C]phosgene affording [11C]RPR-72840A are described. Biodistribution studies in rats and PET studies in baboons were conducted to evaluate [11C]RPR-72840A as a tracer for PET imaging of the serotonin reuptake system.
