Author/Authors :
Hong-Seok Kim، نويسنده , , Bo-Seung Choi، نويسنده , , Kyung-Chan Kwon، نويسنده , , Sang-Ok Lee، نويسنده , , Hyun Jung Kwak، نويسنده , , Cheol Hae Lee، نويسنده ,
Abstract :
Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3β-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine.
