Author/Authors :
Béatrice Bonnet، نويسنده , , David Soullez، نويسنده , , Elisabeth Davioud-Charvet، نويسنده , , Valérie Landry، نويسنده , , Dragos Horvath، نويسنده , , Christian Sergheraert، نويسنده ,
Abstract :
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (Ki = 0.4 μM) is the most potent TR inhibitor described so far.
