Title of article
Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity Original Research Article
Author/Authors
Britt-Marie Swahn، نويسنده , , Karin M. Edvinsson، نويسنده , , Elisabet Kallin، نويسنده , , Ulf Larsson، نويسنده , , Odd-Geir Berge، نويسنده , , H?kan Molin، نويسنده , , Benjamin Pelcman، نويسنده , , Alf Claesson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
7
From page
1293
To page
1299
Abstract
(2R,3S,1′R)-3-(1-Hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 has been synthesized by two different methods. The NMDA receptor binding affinities (Ki values) are 74 nM for compound 1, and 64 nM for the corresponding ketone 2. The analgesic effects were evaluated using the mouse hot-plate test and the mouse formalin model. The ED50 values for the racemates of compounds 1 and 2, using the mouse hotplate and intrathecal injection, were 0.53 and 0.51 nmol, respectively.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301250
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