Author/Authors :
Masaki Tsushima، نويسنده , , Katsuyoshi Iwamatsu، نويسنده , , Eijiro Umemura، نويسنده , , Toshiaki Kudo، نويسنده , , Yasuo Sato، نويسنده , , Sojiro Shiokawa، نويسنده , , Hiromasa Takizawa، نويسنده , , Yuko Kano، نويسنده , , Kazuko Kobayashi، نويسنده , , Takashi Ida، نويسنده , , Atsushi Tamura، نويسنده , , Kunio Atsumi، نويسنده ,
Abstract :
A series of cephalosporins bearing a 5,5-fused ring system, an (imidazo[5,1-b]thiazolium-6-yl)methyl group, at the C-3 position were synthesized and evaluated for in vitro antibacterial activities. CP6679 (1s) and its analogues showed potent antibacterial activities against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. They were also highly active against methicillin-resistant Staphylococcus aureus (MRSA). CP6679 (1s) showed more potent antibacterial activity than ceftazidime (CAZ) or cefpirome (CPR) against Pseudomonas aeruginosa and MRSA.
