Biotransformation of a 4(20),11(12)-taxadiene derivative Original Research Article

A 4(20),11(12)-taxadiene derivative was converted to hydroxylated derivatives by Cunninghamella elegans AS3.2033 and Cunninghamella elegans var chibaensis ATCC 20230. Both microorganisms led to C-1 hydroxylations and conversion to a C-15-hydroxylated abeo-taxane. Additional products from the two fungi differed: a C-14 oxidation and a trans–cis isomerization of the cinnamoyl for one and an unprecedented hydroxylation at C-17 for the other.