Synthesis of sialyl lewis x pentasaccharide analogue for high-throughput screening of selectin blockers Original Research Article

We have developed an effective synthesis of sLex pentasaccharide glycolipid analogue 2. As a part of application of sLex pentasaccharide glycolipid 2 synthesized here, we have investigated the construction of a high-throughput screening system for discovery of selectin blockers. As a result, it was found that compound 2 was a useful ligand for in vitro ELISA assay and could be an important material for high-throughput screening of selectin blockers.