Title of article
Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers Original Research Article
Author/Authors
Mikhail F. Gordeev، نويسنده , , Dinesh V. Patel، نويسنده , , Bruce P. England، نويسنده , , Supriya Jonnalagadda، نويسنده , , Jesse D. Combs، نويسنده , , Eric M. Gordon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
7
From page
883
To page
889
Abstract
Solid-phase synthesis of a 300-member pharmacophore library of 1,4-dihydropyridines from keto ester, diketone and aldehyde building blocks on a cleavable amine polymeric support is described. Screening and serial deconvolution of the combinatorial library has resulted in identification of known and new potent calcium channel blockers.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301587
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