Author/Authors :
K.A. Berryman، نويسنده , , J.J. Edmunds، نويسنده , , A.M. Bunker، نويسنده , , S. Haleen، نويسنده , , J. Bryant، نويسنده , , K.M. Welch، نويسنده , , A.M. Doherty، نويسنده ,
Abstract :
The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure–activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ETA receptor subtype.
