Author/Authors :
Sylvie Bourrain، نويسنده , , Ian Collins، نويسنده , , Joseph G. Neduvelil، نويسنده , , Michael Rowley، نويسنده , , Paul D. Leeson، نويسنده , , Smita Patel، نويسنده , , Shil Patel، نويسنده , , Frances Emms، نويسنده , , Rosemarie Marwood، نويسنده , , Kerry L. Chapman، نويسنده , , Alan E. Fletcher، نويسنده , , Graham A. Showell، نويسنده ,
Abstract :
Two novel series of 3-(heterocyclylmethyl)pyrazoles have been synthesised and evaluated as ligands for the human dopamine D4 receptor. Compounds in series I (exemplified by 8k) have a phenyl ring joined to the 4-position of the pyrazole while those in series II (exemplified by 15j) have a 5-phenyl ring linked by a saturated chain to the 4-position of the pyrazole. Both series supplied compounds with excellent affinity for the human D4 and good selectivity over other dopamine receptors. Excellent selectivity over calcium, sodium, and potassium ion channels was also achieved.
