Title of article :
The structure of McN-5652 Original Research Article
Author/Authors :
Oliver Schulze، نويسنده , , Ulrich Schmidt، نويسنده , , Jürgen Voss، نويسنده , , Bruno Nebeling، نويسنده , , Gunadi Adiwidjaja، نويسنده , , Klaus Scharw?chter، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
The configuration of the diastereoisomers of 6-(4-methylthiophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline 1 (McN-5652) is determined and unequivocally assigned by NMR spectroscopy (NOE measurements) and an X-ray structural analysis of the trans diastereoisomer. The enantiomers of cis-1 are separated by preparative HPLC on a chiral phase. One of the enantiomers of cis-1 represents the precursor for imaging the serotonin 5-HT transporter with positron emission tomography (PET).
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
