Title of article
The structure of McN-5652 Original Research Article
Author/Authors
Oliver Schulze، نويسنده , , Ulrich Schmidt، نويسنده , , Jürgen Voss، نويسنده , , Bruno Nebeling، نويسنده , , Gunadi Adiwidjaja، نويسنده , , Klaus Scharw?chter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
7
From page
2105
To page
2111
Abstract
The configuration of the diastereoisomers of 6-(4-methylthiophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline 1 (McN-5652) is determined and unequivocally assigned by NMR spectroscopy (NOE measurements) and an X-ray structural analysis of the trans diastereoisomer. The enantiomers of cis-1 are separated by preparative HPLC on a chiral phase. One of the enantiomers of cis-1 represents the precursor for imaging the serotonin 5-HT transporter with positron emission tomography (PET).
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2001
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301716
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