• Title of article

    An oxyanion-Hole selective serine protease inhibitor in complex with trypsin Original Research Article

  • Author/Authors

    Jian Cui، نويسنده , , Fatima Marankan، نويسنده , , WenTao Fu، نويسنده , , David Crich، نويسنده , , Andrew Mesecar، نويسنده , , Michael E Johnson، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    6
  • From page
    41
  • To page
    46
  • Abstract
    p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole.
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Serial Year
    2002
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Record number

    1301932

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1301932