Enantioselective synthesis of (+)-4-Demethoxy-1,4-Dimethyldaunomycinone Original Research Article

(+)-4-Demethoxy-1,4-dimethyldaunomycinone 1 was synthesized using a convergent approach. Here, the key tetracyclic compound 10 was assembled by way of a Diels–Alder reaction using the sugar-based diene 8 and the quinizarin-related dienophile 7.