Author/Authors :
J.N Tabudravu، نويسنده , , V.G.H Eijsink، نويسنده , , G.W Gooday، نويسنده , , M Jaspars، نويسنده , , David Komander، نويسنده , , M Legg، نويسنده , , B Synstad، نويسنده , , D.M.F van Aalten، نويسنده ,
Abstract :
Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.
