Author/Authors :
Niranjan P. Sahu، نويسنده , , Chiranjib Pal، نويسنده , , Nirup B. Mandal، نويسنده , , Sukdeb Banerjee، نويسنده , , Mausumi Raha، نويسنده , , Ashis P. Kundu، نويسنده , , Anirban Basu، نويسنده , , Monidipa Ghosh، نويسنده , , Keshab Roy، نويسنده , , Santu Bandyopadhyay، نويسنده ,
Abstract :
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.
