Title of article
Comparison of the Inhibition of Human and Trypanosoma cruzi Prolyl Endopeptidases Original Research Article
Author/Authors
Sandrine Vendeville، نويسنده , , Filip Goossens، نويسنده , , Marie-Ange Debreu-Fontaine، نويسنده , , Valérie Landry، نويسنده , , Elisabeth Davioud-Charvet، نويسنده , , Philippe Grellier، نويسنده , , Simon Scharpe، نويسنده , , Christian Sergheraert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
11
From page
1719
To page
1729
Abstract
Prolyl endopeptidases (PEPs) have been found in numerous species. Inhibitors of human enzyme could correct cognitive deficits in Alzheimer patients while inhibition of Trypanosoma cruzi PEP could prevent invasion phase in Chagas disease. A structure–activity relationship study carried out in a tetrahydroisoquinoline series allowed to obtain potent competitive inhibitors superior to SUAM-1221. Besides, inhibitors expected to act according to an irreversible mechanism revealed to be superior to JPT-4819, for applications linked to human enzyme inhibition.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302102
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