Title of article :
Synthesis and In vitro characterization of a tissue-Selective fullerene: vectoring C60(OH)16AMBP to mineralized bone Original Research Article
Author/Authors :
Kelly A Gonzalez، نويسنده , , Lon J. Wilson، نويسنده , , Wenju Wu، نويسنده , , George H Nancollas، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
A tissue-vectored bisphosphonate fullerene, C60(OH)16AMBP [4,4-bisphosphono-2-(polyhydroxyl-1,2-dihydro-1,2-methanofullerene[60]-61-carboxamido)butyric acid], designed to target bone tissue has been synthesized and evaluated in vitro. An amide bisphosphonate addend, in conjunction with multiple hydroxyl groups, confers a strong affinity for the calcium phosphate mineral hydroxyapatite of bone. Constant composition crystal growth studies indicate that C60(OH)16AMBP reduces hydroxyapatite mineralization by 50% at a concentration of 1 μM, following a non-Langmuirian mechanism. Parallel studies with C60(OH)30 also indicate an affinity for hydroxyapatite, but at a reduced level (28% crystal growth rate reduction at 1 μM) compared with C60(OH)16AMBP. This study is the first to demonstrate that a fullerene-based material can be successfully targeted to a selected tissue as a step toward the development of such materials for medical purposes, in general.
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry