Title of article
Design and synthesis of a selective EP4-receptor agonist. Part 4: practical synthesis and biological evaluation of a novel highly selective EP4-receptor agonist Original Research Article
Author/Authors
Toru Maruyama، نويسنده , , Shin-Itsu Kuwabe، نويسنده , , Yasufumi Kawanaka، نويسنده , , Tai Shiraishi، نويسنده , , Yoshiyuki Shinagawa، نويسنده , , Kiyoto Sakata، نويسنده , , Akiteru Seki، نويسنده , , Yoko Kishida، نويسنده , , Hideyuki Yoshida، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Shinsuke Hashimoto، نويسنده , , Masanori Kawamura، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
8
From page
2103
To page
2110
Abstract
A practical method of synthesizing a highly selective EP4-receptor agonist 1 using Corey lactone 2 as a key intermediate was developed. Selective methanesulfonylation of the primary alcohol of the diol 8 under the newly devised conditions followed by the protection of the remaining secondary alcohol are key reactions in this new method. Further biological evaluation of 1a–b is also reported.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302141
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