Author/Authors :
Toru Maruyama، نويسنده , , Shin-Itsu Kuwabe، نويسنده , , Yasufumi Kawanaka، نويسنده , , Tai Shiraishi، نويسنده , , Yoshiyuki Shinagawa، نويسنده , , Kiyoto Sakata، نويسنده , , Akiteru Seki، نويسنده , , Yoko Kishida، نويسنده , , Hideyuki Yoshida، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Shinsuke Hashimoto، نويسنده , , Masanori Kawamura، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
A practical method of synthesizing a highly selective EP4-receptor agonist 1 using Corey lactone 2 as a key intermediate was developed. Selective methanesulfonylation of the primary alcohol of the diol 8 under the newly devised conditions followed by the protection of the remaining secondary alcohol are key reactions in this new method. Further biological evaluation of 1a–b is also reported.
