Title of article :
Synthesis and Cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione Derivatives Original Research Article
Author/Authors :
Yu-Hua Chao، نويسنده , , Sheng-Chu Kuo، نويسنده , , Kelvin Ku، نويسنده , , I-Ping Chiu، نويسنده , , Chun-Hsiung Wu، نويسنده , , Anthony Mauger، نويسنده , , Hui-Kang Wang، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
2- and 3-Methyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione and related derivatives were synthesized and evaluated in vitro by NCI against eight cancer types. Compounds 12–15 showed significant activity against melanoma, NCI-H23 non-small cell lung cancer, and MDA-MB-435 and MDA-N breast cancer cell lines; 2-hydroxymethyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione (13) showed the highest activity against melanoma (mean log GI50=−7.74) and the highest overall potency (mean log GI50=−6.99).
Keywords :
8-diones , 4 , 2-b:5 , 4-b?]dithiophene-4 , Antineoplastic activity , Cytotoxicity , 4 , Structural modification , 5-b?]dithiophene-4 , 2-b:4 , 8-diones
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
