Title of article
Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation Original Research Article
Author/Authors
Dries B.A. de Bont، نويسنده , , Karen M. Sliedregt-Bol، نويسنده , , Lovina J.F. Hofmeyer، نويسنده , , Rob M.J. Liskamp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
5
From page
1043
To page
1047
Abstract
Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds.
Keywords
peptides and polypeptides , Solid-phase synthesis , aminoacids and derivatives , isosteres
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302306
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