Title of article
Design and synthesis of 3-fluoro-2-oxo-3-phenylpropionic acid derivatives as potent inhibitors of 4-hydroxyphenylpyruvate dioxygenase from pig liver Original Research Article
Author/Authors
Tung-shen Ling، نويسنده , , Cheng-Shi Shiu، نويسنده , , Ding-Yah Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
7
From page
1459
To page
1465
Abstract
Several rationally designed analogs of 3-fluoro-2-oxo-3-phenylpropionic acid were chemically synthesized, and the reactions of the hydrate form of these compounds with 4-hydroxyphenylpyruvate dioxygenase from pig liver as inhibitors were examined. Compounds 14a and 14b were found to be potent competitive inhibitors of the enzyme with Ki values of 10 and 22 μM, respectively.
Keywords
Enzyme inhibition , hydrate form , keto form , HPPD
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302352
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