Title of article
Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma Original Research Article
Author/Authors
Allan M. Jordan، نويسنده , , Tariq H. Khan، نويسنده , , Helen M.I Osborn، نويسنده , , Andrew Photiou، نويسنده , , Patrick A. Riley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1775
To page
1780
Abstract
A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not.
Keywords
Tyrosinase , Melanoma , antitumour compound , Prodrug
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302385
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